For over thirty-seven years, Margaret and Olaus Murie made their home in the mountainous wilderness of the Tetons, where Olaus Murie conducted his famous studies of the American elk, the wapiti. Through these years their home was almost a nature-conservation shrine to thousands of Americans interested in the out-of-doors, in animals, in nature in general. Wapiti Wilderness, begun by Mrs. Murie as a sequel to her Two in the Far North, which told of the Muries' life and expeditions in Alaska, became a book written by both the Muries.

In alternate chapters, Olaus tells of his work as a field biologist for the old U.S. Bureau of Biological Survey and recounts stories of his studies of the elk and the other great animals of the West. And Mrs. Murie, from her side, describes their life together, on the trail, in the various camps, and nature adventures in that wilderness in all seasons. The book is replete with stories of Jackson Hole people, "pioneer poets," and the wild creatures that made their way into the Murie household. Olaus Murie's evocative pen-and-ink drawings illuminate each chapter, and four pages of photographs help complete the picture of what life was like in the wapiti wilderness.